| Angiotensin
I converting enzyme (ACE) gene Insertion / Deletion (I/D) polymorphism
is associated with exercise trainability and exercise induced left
ventricular hypertrophy. However, it is unclear whether this polymorphism
influences exercise trainability in the elderly, and the electrocardiological
alterations by exercise training is unknown among the genotypes. We
herein investigated the association between ACE gene insertion/deletion
(I/D) polymorphism, exercise trainability and the electrocardiological
alternations by exercise in elderly women. Eighty four elderly women
participated in this study. In all subjects the leg extension power
(LEP) and lactate threshold (LT) were determined in order to evaluate
the muscle strength, aerobic capacity and to also select the appropriate
training intensity for each individual. They performed bench step
exercise training for 12 weeks. A resting electrocardiogram was recorded
for the obtained QTc interval in before and after the program. The
baseline of aerobic capacity was higher in I/I than that in I/D, and
the QTc interval was shorter in I/I than that in I/D. All other characteristics
were similar among the genotypes. The QTc interval tended to be shorten
only in the D/D. Furthermore, the value of the QTc interval change
showed a significant difference between the I/I and D/D genotype after
the program. The LT and LEP demonstrated a similar response among
the genotypes. The D allele of ACE gene I/D polymorphism may therefore
play a role in the electrocardiological aspect during exercise training,
however, it was not found to influence the aerobic capacity.
KEY
WORDS: Electrophysiology, exercise, genes.
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