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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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RED BLOOD CELL AND WHOLE BLOOD GLUTATHIONE REDOX STATUS IN ENDURANCE-TRAINED MEN FOLLOWING A SKI MARATHON |
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Eve Unt1  ,
Ceslava Kairane2, Ivi Vaher1 and Mihkel Zilmer2 |
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1Institute of Exercise Biology and Physiotherapy, 2Department of Biochemistry, University of Tartu, Tartu, Estonia |
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© Journal of Sports Science and Medicine (2008) 7, 344 - 349 Search Google Scholar for Citing Articles |
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| ABSTRACT | |||
| The aim of the present study was to evaluate the changes in glutathione
redox ratio (GSSG·GSH-1) in red blood cells (RBCs) and whole blood in well-trained
men following a ski marathon. 16 male subjects (27.0 ± 4.7 yrs, 1.81 ± 0.06
m, 77.6 ± 9.6 kg, VO2max 66.2 ± 5.7 ml·kg-1·min-1)
were examined before the competition (pre- COMP), after the competition
(post-COMP) and during an 18-hour recovery period (RECOV). There was a slight
decrease in reduced glutathione (GSH) in blood and in RBCs in post-COMP.
During RECOV, the GSH level in blood was reduced, the GSH level in RBCs
was significantly elevated (a statistically significant difference as compared
to the pre-COMP level). The post-COMP GSSG·GSH-1 in full blood did not increase
significantly, but its increase was statistically significant during the
18-hour recovery period. During the post-COMP and RECOV, the GSSG·GSH-1
in RBCs slightly decreased in comparison with the pre-COMP. Vitamin C concentration
in serum increased in post-COMP (49% vs. pre- COMP) and decreased to the
baseline level during RECOV. In conclusion, our data show that acute exercise
slightly increases the GSSG·GSH-1 in whole blood, while GSSG·GSH-1 in RBCs
significantly decreases. Thus, exercise-related changes in the non-enzymatic
components of the glutathione system (GSSG and GSH) in whole blood and RBCs
are not identical.
Key words: Free radicals, antioxidants, glutathione, vitamin C, exercise. |
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