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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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CAPSAICIN SUPPLEMENTATION FAILS TO MODULATE AUTONOMIC AND CARDIAC ELECTROPHYSIOLOGIC ACTIVITY DURING EXERCISE IN THE OBESE: WITH VARIANTS OF UCP2 AND UCP3 POLYMORPHISM |
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Ki Ok Shin1,2 
and Toshio Moritani2 |
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1Research Institute of Sport Science, Pusan National University, Geumjeong-gu, Busan 609735, Korea 2Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto 6068501, Japan |
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© Journal of Sports Science and Medicine (2008) 7, 365 - 370 Search Google Scholar for Citing Articles |
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| ABSTRACT | |||
| We investigated the effects of capsaicin supplementation (150mg)
on alterations of autonomic nervous system (ANS) activity associated with
adverse effects of cardiac depolarization-repolarization intervals during
aerobic exercise in obese humans. Nine obese males (26.1 ± 1.5 yrs) volunteered
between study designed. The cardiac ANS activities evaluated by means of
heart rate variability of power spectral analysis and cardiac QT interval
were continuously measured during 5-min rest and 30-min exercise at 50%
of maximal ventilation threshold (50%VTmax) on stationary ergometer with
placebo (CON) or capsaicin (CAP) oral administration chosen at random. The
uncoupling protein (UCP) 2 and UCP 3 genetic variants of the subjects were
analyzed by noninvasive genotyping method from collecting buccal mucosa
cells. The results indicated that there were no significant differences
in cardiac ANS activities during rest and exercise between CON and CAP trials.
Although no significant difference, A/A allele of UCP2 polymorphism showed
a reduced sympathetic nervous system (SNS) index activity compared to G/G
+ G/A allele during exercise intervention in our subjects. On the other
hand, the data on cardiac QT interval showed no significant difference,
indicating that oral administration of capsaicin did not cause any adverse
effect on cardiac depolarization-repolarization. In conclusion, our results
suggest that capsaicin supplementation 1 h before exercise intervention
has no effect on cardiac ANS activities and cardiac electrical stability
during exercise in obese individuals. Further studies should also consider
genetic variants for exercise efficacy against obesity.
Key words: Heart rate variability power spectral analysis, cardiac depolarization-repolarization interval, uncoupling protein, capsaicin, exercise. |
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