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JOURNAL
OF
SPORTS SCIENCE &
MEDICINE
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Research
article
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A COMMON VARIATION IN THE PROMOTER REGION OF INTERLEUKIN-6 GENE SHOWS ASSOCIATION WITH EXERCISE PERFORMANCE |
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Antti Huuskonen1, Minna Tanskanen2, Jani Lappalainen1, Niku Oksala1,3, Heikki Kyröläinen2 and Mustafa Atalay1  |
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1Institute of Biomedicine, Physiology, University of Kuopio, Finland, 2Department of Biology of Physical Activity, University of Jyväskylä, Finland, 3Department of Surgery, Tampere University Hospital, Finland. |
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© Journal of Sports Science and Medicine (2009) 8, 271 - 277 Search Google Scholar for Citing Articles |
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| ABSTRACT | |||
| Skeletal muscle-derived interleukin-6 (IL-6) is a pleiotropic
cytokine which regulates body metabolism during strenuous physical exercise.
OBJECTIVE: The effect of a potentially functional single nucleotide polymorphism
(SNP) -174G/C of the IL6 gene (rs1800795) promoter was examined on maximal
oxygen uptake (VO2max), body mass index (BMI) and plasma IL-6
levels in response to physical training. Fifty four male military conscripts
were studied for 8 weeks during their basic training. At weeks 1, 5 and
8, VO2max and anthropometrics were measured, and blood samples
collected before and after acute aerobic exercise. Acute exercise increased
plasma IL-6 in subjects with genotype CG. Moreover, during the 8-week training
period, a tendency for increased plasma IL-6 was observed in subjects with
this genotype. VO2max values increased in all genotype groups,
but subjects with genotype CG made the greatest gains in VO2max.
Training significantly decreased BMI only in subjects with genotype CG.
Our findings suggest that the allele C may have an effect on plasma IL-6
response to acute exercise in healthy male subjects. Exercise training has
a favourable effect on VO2max and BMI, with the most prominent
effects in subjects with genotype CG. Thus we conclude that this SNP may
account for individual response to exercise training.
Key words: Maximal oxygen uptake, IL-6, polymorphism, body mass index, training. |
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